Not necessarily, no. I don't expect many developers to go this route, and - in fact - drum roll please.... Bitsum may be the company that helps to protect executables from inappropriate external adjustments. We saw this problem start to emerge as crapware snake-oil PC optimization companies started to try to copy our technology, but failed miserably at it. So, if we're the ones protecting, we are also the ones who can still take action.
Letting a secret out of the bag here, but so be it.
However, I don't expect wide-spread use of self-protecting applications maybe ever.. they will probably always be the minority. Games are doing so because of cheats and such, other applications (excepting security suites) have no need, and it causes a lot of complications, so will not go this route.